Sep 16, 2026, 11:00 AM CUT
2026 NFL Week 2 odds: Lines and possibilities for all 16 games
ARLINGTON, TX - DECEMBER 14: A Dallas Cowboys helmet sits onto a cooler during the game between the Dallas Cowboys and the Minnesota Vikings on December 14, 2025 at AT&T Stadium in Arlington, Texas. Photo by Matthew Pearce/Icon Sportswire NFL, American Football Herren, USA DEC 14 Vikings at Cowboys EDITORIAL USE ONLY Icon1692512141231
ARLINGTON, TX - DECEMBER 14: A Dallas Cowboys helmet sits onto a cooler during the game between the Dallas Cowboys and the Minnesota Vikings on December 14, 2025 at AT&T Stadium in Arlington, Texas. Photo by Matthew Pearce/Icon Sportswire NFL, American Football Herren, USA DEC 14 Vikings at Cowboys EDITORIAL USE ONLY Icon1692512141231
Week 2 opens with the Detroit Lions visiting the Buffalo Bills on Thursday night, with Buffalo entering the matchup as a 4.5-point favorite. The game also carries the highest over/under of the Week 2 slate at 53.5 points.
Here are the lines for all 16 Week 2 matchups at bet365 Sportsbook as of Sept. 15, including the spread, moneyline and over/under.
1. Detroit Lions @ Buffalo Bills
The Bills are 4.5-point favorites against the Lions, with Buffalo listed at -225 on the moneyline and Detroit at +185. The over/under is set at 53.5 points, the highest total among the Week 2 matchups.
2. Carolina Panthers @ Atlanta Falcons
The Panthers are 1.5-point favorites against the Falcons. Carolina is listed at -125 on the moneyline, while Atlanta is +105, with the over/under set at 43.5 points.
3. Cincinnati Bengals @ Houston Texans
According to Fox Sports, the Texans are favored by three points against the Bengals. Houston has a -155 moneyline compared with +130 for Cincinnati, while the over/under is set at 46.5 points.
CINCINNATI, OH - DECEMBER 14: A Cincinnati Bengals helmet sits on the bench during the game against the Baltimore Ravens and the Cincinnati Bengals on December 14, 2025, at Paycor Stadium in Cincinnati, OH. Photo by Ian Johnson/Icon Sportswire NFL, American Football Herren, USA DEC 14 Ravens at Bengals EDITORIAL USE ONLY Icon251214108
CINCINNATI, OH - DECEMBER 14: A Cincinnati Bengals helmet sits on the bench during the game against the Baltimore Ravens and the Cincinnati Bengals on December 14, 2025, at Paycor Stadium in Cincinnati, OH. Photo by Ian Johnson/Icon Sportswire NFL, American Football Herren, USA DEC 14 Ravens at Bengals EDITORIAL USE ONLY Icon251214108
4. Cleveland Browns @ Tampa Bay Buccaneers
The Buccaneers are 8.5-point favorites over the Browns and are listed at -425 on the moneyline. Cleveland is +325, with the over/under set at 41.5 points.
5. Green Bay Packers @ New York Jets
The Packers enter as 3.5-point favorites against the Jets. Green Bay is priced at -200 on the moneyline, while New York is +165, and the over/under is 44.5 points.
6. Minnesota Vikings @ Chicago Bears
The Bears are favored by 5.5 points against the Vikings. Chicago is listed at -240 on the moneyline, compared with +195 for Minnesota, while the over/under stands at 48.5 points.
7. New Orleans Saints @ Baltimore Ravens
The Ravens are 8.5-point favorites against the Saints, with Baltimore carrying a -425 moneyline. New Orleans is listed at +325, while the over/under is set at 46.5 points.
8. Philadelphia Eagles @ Tennessee Titans
The Eagles are seven-point favorites against the Titans. Philadelphia is listed at -340 on the moneyline, while Tennessee is +270, with the over/under set at 39.5 points.
9. Pittsburgh Steelers @ New England Patriots
The Patriots are favored by 5.5 points over the Steelers. New England is listed at -245 on the moneyline, compared with +200 for Pittsburgh, while the over/under is 41.5 points.
10. Jacksonville Jaguars @ Denver Broncos
The Broncos are 2.5-point favorites against the Jaguars. Denver has a -140 moneyline, while Jacksonville is +120, with the over/under set at 44.5 points.
11. Las Vegas Raiders @ Los Angeles Chargers
The Chargers are favored by seven points against the Raiders. Los Angeles is listed at -320 on the moneyline, compared with +260 for Las Vegas, while the over/under is 43.5 points.
12. Miami Dolphins @ San Francisco 49ers
The 49ers have the largest spread of the Week 2 slate at -13.5 against the Dolphins. San Francisco is listed at -900 on the moneyline, while Miami is +600, with the over/under set at 45.5 points.
13. Seattle Seahawks @ Arizona Cardinals
The Seahawks are 4.5-point favorites against the Cardinals. Seattle is listed at -220 on the moneyline, while Arizona is +180, with the over/under set at 41.5 points.
14. Washington Commanders @ Dallas Cowboys
The Cowboys are favored by 3.5 points against the Commanders. Dallas has a -210 moneyline compared with +175 for Washington, while the over/under is set at 50.5 points.
15. Indianapolis Colts @ Kansas City Chiefs
The Chiefs are 6.5-point favorites against the Colts. Kansas City is listed at -310 on the moneyline, while Indianapolis is +250, with the over/under set at 47.5 points.
16. New York Giants @ Los Angeles Rams
The Rams close out Week 2 as 7.5-point favorites against the Giants. Los Angeles is listed at -350 on the moneyline, compared with +275 for New York, while the over/under is 48.5 points.
As Week 2 approaches, the spread differences give an early indication of how closely matched or one-sided sportsbooks expect each matchup to be. The odds can change before kickoff, so the latest numbers will be worth checking closer to game day.
Written by
Divyanshi Raj