Week 2 opens with the Detroit Lions visiting the Buffalo Bills on Thursday night, with Buffalo entering the matchup as a 4.5-point favorite. The game also carries the highest over/under of the Week 2 slate at 53.5 points.

Here are the lines for all 16 Week 2 matchups at bet365 Sportsbook as of Sept. 15, including the spread, moneyline and over/under.

1. Detroit Lions @ Buffalo Bills

The Bills are 4.5-point favorites against the Lions, with Buffalo listed at -225 on the moneyline and Detroit at +185. The over/under is set at 53.5 points, the highest total among the Week 2 matchups.

2. Carolina Panthers @ Atlanta Falcons

The Panthers are 1.5-point favorites against the Falcons. Carolina is listed at -125 on the moneyline, while Atlanta is +105, with the over/under set at 43.5 points.

3. Cincinnati Bengals @ Houston Texans

According to Fox Sports, the Texans are favored by three points against the Bengals. Houston has a -155 moneyline compared with +130 for Cincinnati, while the over/under is set at 46.5 points.

4. Cleveland Browns @ Tampa Bay Buccaneers

The Buccaneers are 8.5-point favorites over the Browns and are listed at -425 on the moneyline. Cleveland is +325, with the over/under set at 41.5 points.

5. Green Bay Packers @ New York Jets

The Packers enter as 3.5-point favorites against the Jets. Green Bay is priced at -200 on the moneyline, while New York is +165, and the over/under is 44.5 points.

6. Minnesota Vikings @ Chicago Bears

The Bears are favored by 5.5 points against the Vikings. Chicago is listed at -240 on the moneyline, compared with +195 for Minnesota, while the over/under stands at 48.5 points.

7. New Orleans Saints @ Baltimore Ravens

The Ravens are 8.5-point favorites against the Saints, with Baltimore carrying a -425 moneyline. New Orleans is listed at +325, while the over/under is set at 46.5 points.

8. Philadelphia Eagles @ Tennessee Titans

The Eagles are seven-point favorites against the Titans. Philadelphia is listed at -340 on the moneyline, while Tennessee is +270, with the over/under set at 39.5 points.

9. Pittsburgh Steelers @ New England Patriots

The Patriots are favored by 5.5 points over the Steelers. New England is listed at -245 on the moneyline, compared with +200 for Pittsburgh, while the over/under is 41.5 points.

10. Jacksonville Jaguars @ Denver Broncos

The Broncos are 2.5-point favorites against the Jaguars. Denver has a -140 moneyline, while Jacksonville is +120, with the over/under set at 44.5 points.

11. Las Vegas Raiders @ Los Angeles Chargers

The Chargers are favored by seven points against the Raiders. Los Angeles is listed at -320 on the moneyline, compared with +260 for Las Vegas, while the over/under is 43.5 points.

12. Miami Dolphins @ San Francisco 49ers

The 49ers have the largest spread of the Week 2 slate at -13.5 against the Dolphins. San Francisco is listed at -900 on the moneyline, while Miami is +600, with the over/under set at 45.5 points.

13. Seattle Seahawks @ Arizona Cardinals

The Seahawks are 4.5-point favorites against the Cardinals. Seattle is listed at -220 on the moneyline, while Arizona is +180, with the over/under set at 41.5 points.

14. Washington Commanders @ Dallas Cowboys

The Cowboys are favored by 3.5 points against the Commanders. Dallas has a -210 moneyline compared with +175 for Washington, while the over/under is set at 50.5 points.

15. Indianapolis Colts @ Kansas City Chiefs

The Chiefs are 6.5-point favorites against the Colts. Kansas City is listed at -310 on the moneyline, while Indianapolis is +250, with the over/under set at 47.5 points.

16. New York Giants @ Los Angeles Rams

The Rams close out Week 2 as 7.5-point favorites against the Giants. Los Angeles is listed at -350 on the moneyline, compared with +275 for New York, while the over/under is 48.5 points.

As Week 2 approaches, the spread differences give an early indication of how closely matched or one-sided sportsbooks expect each matchup to be. The odds can change before kickoff, so the latest numbers will be worth checking closer to game day.

Written by

Divyanshi Raj